Prof. Sanaa Botros, Professor of Pharmacology-TBRI


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• State Appreciation Award in Advanced Technological Sciences in the Field of Medical Sciences, (2015).

Theodor Bilharz Research Institute Appreciation Award from Theodor Bilharz Research Institute, (2014)

Excellence Award from Theodor Bilharz Research Institute for Innovation, Success in Collaboration with International Organizations and Good Administration, (2001).



Certificate of Excellence from Theodor Bilharz Research Institute Silver Jubilee, (2003).

State Encouragement Award in Medical Sciences, (1997).

Prof. Ibrahim Mostafa, Professor of Hepatologastroenterology-TBRI




State Appreciation Award in Advanced Technological Sciences in the Field of Medical Sciences, (2014).


Master of World Gastroenterology Organization


Honorary Fellow of The Royal College of Physicians, Glasgow, UK.

Prof. Mohamed Mohei El-Wishahy, Professor of Urology



State Encouragement Award in Medical Sciences, (1993).

Prof. Hanan Farouk Khafagy, Professor of Anesthesiology



State Encouragement Award in Medical Sciences, (2007).

Associate Prof. Ahmed Abdel Aziz, Associate Professor of General Surgery



State Encouragement Award in Medical Sciences, (2014).

Dr. Mohamed Hosny, Researcher of Interventional Radiology



State Encouragement Award in Medical Sciences, (2014).

African Network for Drugs and Diagnostics Innovation Award, (2011) in Diagnostics (Immunology Laboratory) Drug Innovations (Pharmacology Laboratory)

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Prof. Sanaa Botros, Professor of Pharmacology-TBRI


African Union Women Scientists Regional Award in Earth and Life Sciences, (2009).

Arab Women Organization Award for Science and Technology in Biological Sciences, (2008).

Prof. Sanaa Botros, Professor of Pharmacology-TBRI




• Cited in the Fourth International Directory of Distinguished Leadership,(1992) by the American Biographical Institute, Raleig North Carolina, U.S.A


Issued Patents

  1.      Diaphragm-Controlled Tracheobronchial Tube (DC-TBT) for one lung anesthesia

      This tube can be used for one lung anesthesia in all age groups. The design has the advantage of decreasing airway resistance as compared to the regular double-lumen tube.

 •      Submitted in 2008, no. 24054






     Principle investigator: Prof. Hossam El-Din Helmy


2.      Multi-Directional Intubating Laryngeal Mask Airway


A new design of intubating laryngeal mask airway (I-LMA) in cases of difficult intubation. It contains a bundle of tubes with multiple holes in their walls to permit gas flow freely. 

Submitted in 2013, no. 1277

     Investigators: Prof. Hossam El-Din Helmy and Prof. Mohamed Zeidan


3.      Web-based Diagnosis of parasitic diseases using I-Phone

The Digital Parasitological Examination Program (DEPP) is a web service using the iPhone/iPad or any digital tool to capture an image of a specimen. Web services offers differentiation and genotyping for a large number of parasites, recognition of parasite eggs, oocyts or worms and identification of the intensity of infection and specification of the recommended treatment.



      Temporary patency is issued (submitted in 2016, no. 16).

      Principle Investigator: Associate Prof. Rabab Sayed Zalat

      Email:  rababzalat@


Pending Patents

1.      A device for epidural identification and catheterization using continuous hydrostatic pressure

A new technique for identification of the epidural space by reversing the flow mode leading to a simple and accurate identification as well as an easier catheter insertion throughout widening of the epidural space with a minimal applied pressure (50-60 mm Hg).

Description: Poster

      Submitted in 2009, no. 871

      Investigators: Prof. Hossam El-Din Helmy and Prof. Yasser Samhan


2.      Anesthesia device using distilled water injector to get rid of carbon dioxide physically


This invention is a device for anesthesia using distilled-water injector to get rid of carbon dioxide physically to be added as an alternative to the caustic soda lime used in regular anesthesia devices.







 Submitted in 2011, no. 1028

Investigators: Prof. Hossam El-Din Helmy and Prof. Mohamed Zeidan



3.      Construction of plasmid vector for protein expression in prokaryotic cells Named as (pTBRI)

The innovative plasmid is characerized by the presence of the sequence coding for the enzyme T7 RNA polymerase into the construction of plasmid. It allows the possibility of cloning and expression of genes to be used in the production of proteins within normal cells without the need for genetically modified cells of bacteria such as Escherichia coli. Great importance of this innovation is the use in the production of proteins and genetic engineer in Egypt.

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      Submitted in 2012, no. 2162/2012

      Principle Investigator: Prof. Mohamed Saber



4.      In Silico Design and Experimental Validation of siRNAs Targeting Conserved Regions of Multiple Hepatitis C Virus Genotypes

This study reported the design and validation of small interfering RNAs (siRNAs) targeting highly conserved regions of the hepatitis C virus (HCV) genome. This was achieved using an in silico design and selection protocol complemented by an automated MysiRNA-Designer pipeline. Under this strict selection process, two siRNAs (HCV353 and HCV258) were selected based on their predicted high specificity and potency, where they efficiently inhibited HCV RNA replication and also inhibited replication of patient-derived HCV genotype 4 isolates in infected Huh-7cells.

      Submitted in 2012, no. 1679

      Investigators: Prof. Mahmoud El-Hefnawy and Prof. Eman Al-Ahwany


5.      Biomphalaria alexanandrina snails control using silver nanoparticles and chlorophyllin derivatives

This study introduces smart tools for controlling bilharziasis using novel modalities namely; photothermal and photosensitization techniques. Silver nanoparticles (SNPs) along with Magnesium and Copper Chlorophyllin were the studied smart candidate chromophores. The sub-lethal doses of each chromophore (LC25&LC10) were capable of inducing significant change of egg laying rate, growth rate and the ability of the studied Biomphalaria alexandrina snails to be infected with miracidia hence, they can be safely considered promising smart snail eradicating agents and consequently tools to control the prevalence of bilharziasis.

      Submitted in 2013, no. 000020

      Investigator: Prof. Tarek Ahmed, Prof. Mohamed El-Emam and Prof. Mona Ragheb


6.      Praziquantel in a clay nanoformulation shows more bioavailability and higher efficacy against murine Schistosoma mansoni infection

In this study, the biological characteristics of the already-existing antischistosomal praziquantel (PZQ) were improved by incorporating it into montmorillonite clay as a delivery carrier to overcome its known bioavailability drawbacks. This new nano-formulation provided better bioavailability, enhanced antischistosomal efficacy where the dose necessary to kill 50% of the worms was reduced by>3-fold.

      Submitted in 2014, no. 1708

      Investigators: Gina S. El-Feky, Wael S. Mohamed, Hanaa E. Nasr, Naglaa M. El-Lakkany, Sayed H. Seif el-Din, Sanaa S. Botros


7.      Preparation of Single-domain antibodies and graphene coated magnetic metal nanoparticles

Magnetic nanoparticles are employed in numerous areas of medical studies. The invented nanoparticle comprises a targeting moiety conjugated directly or indirectly (e.g., attached via an intermediate polymer) to the graphene coating and use it for diagnosis and or treatment of different infectious diseases.

      Submitted in 2015, no. 14/235

      Principle investigator: Prof. Ibrahim R. Aly


8.      Production of High Therapeutic Efficacy rhIFNα-2b  conjugated with multiple branched PEG polymer

IFNanimated(320x237)Recombinant human IFN-α2b is conjugated with 40 KDa, multiply branched PEG molecule to minimize the loss of bioactivity while retaining good pharmacokinetic properties and increased therapeutic efficacy. It is developed for the production of high efficacy therapeutic compound for treatment of HCV infected patients.







      Submitted in 2016, no. 522/2016

      Principle investigator: Prof. Ehab El-Dabaa



9.      High efficacy compound of recombinant human interferon alpha 2b conjugated with tetrameric branched polyethylene glycol and its preparation

The developed production process included feed batch fermentation, purification of non-soluble inclusion bodies and their solublization, refolding of protein to its native 3ry structure and purification of natural form of the protein from other isoforms followed by pegylation of the purified protein and purification of monopegylated IFN-α2b using chromatographic methods.



Submitted in 2016, no. 521

      Principle investigator: Prof. Ehab El-Dabaa



10.  Impact of Moringa oleifera seeds aqueous extract on some biological, biochemical and histological aspects of Biomphalaria alexandrina snails

This study revealed the molluscicidal activity of aqueous extract of Moringa oleifera seeds againstB. alexandrina snails the intermediate host of Schistosoma mansoni. Exposure of snails to the sub lethal concentrations of this aqueous extract caused a considerable reduction in survival rates and hatchability rates of eggs of these snails. Also, it revealed severe damage in the digestive glands of the snails. The aqueous seed extract of M. oleifera is safe, cheap, biodegradable, easy for application without any harmful effects, besides, it can be used in purification of water.

      Submitted in 2017, no. 1633/73

      Investigator: Prof. Abol fotouh Mohamed and Dr. Amina Mohamed


11.  The establishment of a nano-chip as a rapid and multiple detector to diagnose parasites

This work aimed to manufacturing vertical-flow strip nano-chip kit with graphine nanoparticles and evaluating its role as a simple, rapid, low-cost, sensitive, specific, and user-friendly diagnostic tool for diagnosis of multiple parasitic diseases in one kit.

      Submitted in 2017, no. 837

      Principle investigator: Prof. Ibrahim R. Aly